Meet John F.
John is a health-conscious 55-year-old, who generally feels well and wants to continue his full life. His father had early onset dementia in his early 70s, and his younger brother, 52, just had a coronary stent placed. Because of his father’s rapid decline, he is worried his 60’s will be his last “good” decade. He is unsure if his regular check-ups and routine care will actually address what might be the invisible roots of disease in his heart and in his cognition.
Why Applied Genomics for Longevity?
Applied Genomics for Longevity will give him a broad understanding and personalized action plan related to his own genetics in areas like cardiovascular disease, dementia, and brain aging. Further testing may be recommended or ordered as well.
Analysis
After we initiated testing through the premium service IntellxxDNA™ and ordered some routine labs that helped us assess cardiovascular risk, dementia risk, hormone levels, certain vitamin and mineral levels, glucose and insulin labs, and others as needed, we were able to analyze John F’s results.
Several important pathways were identified that needed attention. John’s B12 absorption protein had a variation that predicted less efficient absorption, and along with a variant B12 transporter to the brain that might not work that well, we had concerns that his levels of B12 needed to be higher than other people’s.
He also was also found to have several variants in his BDNF gene, which codes for brain-derived neurotropic growth factor, a key protein that is involved with many “caretaking” roles in maintaining neurons (brain cells) and their communication. These were two key areas that might relate to his brain aging concerns, and are completely actionable.
The Result
To mitigate non-optimal B12 absorption and achieve higher than usual blood levels, he was recommended to have B12 subcutaneously monthly and to maintain “high-normal” target levels.
In response to the BDNF gene variants and their relationship to neurotropic growth factor, we reviewed all of the tools that increase production of this hormone, including more intense, interval-style exercise, sauna, optimizing deep sleep, and use of lion’s mane mushroom, among other techniques.
Although these two findings are a small subset of the useful data, John F. can implement these lifestyle changes and supplements, knowing they are based on his personal genomic patterns and family history. Although the patient genomic report is 160 pages, we can focus on the top four or five most important clues and prioritize goals for him. The intent is to address problems proactively, before symptoms or a diagnosis.